Enantioselective synthesis of (-)-paeonilide.
نویسندگان
چکیده
The first enantioselective synthesis of (-)-paeonilide is reported. Starting from inexpensive furan-3-carboxylic acid the targeted monoterpene was obtained in 12 steps via an asymmetric cyclopropanation-lactonization cascade and a stereoselective side chain insertion at an acetal-like position.
منابع مشابه
Facile synthesis of (+/-)-paeonilide.
(+/-)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 28 شماره
صفحات -
تاریخ انتشار 2012